USP16

Across TCGA cell cohorts, USP16 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,111 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible USP16-associated GO terms across cancer lineages are Positive regulation of translational elongation, Regulation of mitotic sister chromatid segregation, and Regulation of sister chromatid segregation. Each is linked with USP16 in more than 14 cancer types. Because this analysis shows association rather than direction, both USP16-to-partner and partner-to-USP16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of translational elongation grouped by USP16-low versus USP16-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USP16→partner) and Y-score (partner→USP16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Positive regulation of translational elongation →	+0.156	+1.428	<.001	<.001	3	15
SOFT_TISSUE	Regulation of mitotic sister chromatid segregation →	+0.137	+0.589	<.001	<.001	3	15
SOFT_TISSUE	Regulation of sister chromatid segregation →	+0.128	+0.689	<.001	<.001	3	14
SOFT_TISSUE	Regulation of chromosome segregation →	+0.136	+0.619	<.001	<.001	3	14
OVARY	Protein localization to condensed chromosome →	+0.155	+0.743	<.001	<.001	3	14
OVARY	Microtubule polymerization →	+0.109	+0.841	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,111 associations by consensus.

Positive regulation of translational elongation by USP16 expression — URINARY_TRACT

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