USP14

Across TCGA pan-cancer cohorts, USP14 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated USP14 data layer compared with 27 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher USP14 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated USP14 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUSC, KICH, and ESCA are the cancer types where USP14 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.147	0.776	.001	36	view →
KICH	DFS	Median	All	0.035	0.904	<.001	30	view →
ESCA	DFS	Median	II,III,IV	0.107	0.522	.012	12	view →
BLCA	OS	Median	III,IV	0.205	0.582	.014	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	DFS	Median	All	0.959	0.633	.029	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

USP14–LUSC (OS)

Open the LUSC breakdown →