USP14

Across TCGA pan-cancer cohorts, USP14 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated USP14 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher USP14 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated USP14 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC, COAD, and LUAD are the cancer types where USP14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	0.916	0.602	.005	13	view →
COAD	DFS	Tertile	All	0.919	1.000	.034	12	view →
LUAD	OS	Quartile	II,III,IV	0.290	0.868	.005	12	view →
LSCC	OS	Median	III,IV	0.664	0.996	.015	5	view →
PDAC	OS	Median	II,III,IV	0.288	0.422	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

USP14–CCRCC (DFS)

Open the CCRCC breakdown →