USP14

Across TCGA patient cohorts, USP14 protein abundance is significantly associated with the RNA expression of many other genes, with 6,572 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible USP14-associated genes across cancer lineages are THOC1, SEH1L, and CEP76. Each is linked with USP14 in more than 6 cancer types. Because this analysis shows association rather than direction, both USP14-to-partner and partner-to-USP14 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USP14 versus THOC1 in LSCC, with a Pearson correlation of 0.68.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP14→partner) and Y-score (partner→USP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	THOC1 →	+0.758	+0.351	<.001	<.001	3	7
COAD	SEH1L →	+0.673	+0.234	<.001	<.001	3	7
LSCC	CEP76 →	+0.702	+0.302	<.001	<.001	3	6
COAD	PSMG2 →	+0.570	+0.232	<.001	<.001	3	6
COAD	NAPG →	+0.616	+0.237	<.001	<.001	3	6
BRCA	RALBP1 →	+0.675	+0.339	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,572 associations by consensus.

USP14 vs THOC1 — LSCC

Explore this scatter interactively →