USP14

Across TCGA cell cohorts, USP14 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,583 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible USP14-associated GO terms across cancer lineages are Meiotic spindle assembly, Regulation of metaphase/anaphase transition of cell cycle, and Regulation of mitotic metaphase/anaphase transition. Each is linked with USP14 in more than 15 cancer types. Because this analysis shows association rather than direction, both USP14-to-partner and partner-to-USP14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Meiotic spindle assembly grouped by USP14-low versus USP14-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USP14→partner) and Y-score (partner→USP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Meiotic spindle assembly →	+0.118	+0.729	.001	.002	3	16
UPPER_AERODIGESTIVE_TRACT	Regulation of metaphase/anaphase transition of cell cycle →	+0.123	+1.092	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Regulation of mitotic metaphase/anaphase transition →	+0.128	+1.140	<.001	<.001	3	15
BREAST	Regulation of mitotic sister chromatid segregation →	+0.134	+0.951	.001	<.001	3	15
PANCREAS	Immunoglobulin heavy chain V-D-J recombination →	+0.182	+0.942	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of spindle checkpoint →	+0.115	+1.047	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,583 associations by consensus.

Meiotic spindle assembly by USP14 expression — PANCREAS

Explore this box plot interactively →