Q-omics provides the consensus-scored USP12PX profile across patient tissues and cancer cell-line models. USP12PX expression is associated with patient survival in 14 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, USP12PX is differentially expressed in 7, with the highest sampling consensus in PAAD. Additionally, USP12PX RNA expression shows 9,856 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UVM, and PAAD as cancer lineages where USP12PX shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for USP12PX — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes USP12PX survival associations across molecular data types. USP12PX RNA expression shows survival associations in the most cancer types (14). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible USP12PX RNA expression–survival associations across cancer types. High USP12PX expression shows unfavorable associations in UVM, DLBC, SARC, COAD and READ, but favorable associations in KIRC. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for USP12PX RNA expression.
This table summarizes USP12PX tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7. The strongest signals are observed in PAAD for RNA.
This table ranks reproducible tumor–normal expression differences for USP12PX. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. USP12PX shows lower tumor expression in PAAD, UCEC, READ, LUSC, LUAD and THCA. The PAAD box plot shows higher USP12PX RNA expression in normal versus tumor tissue (log2 FC = −0.090, t-test p = .012).
This table shows molecular features associated with USP12PX in patient tissues and cancer cell lines. In patient samples, USP12PX shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
