USP12-AS2

Across TCGA pan-cancer cohorts, USP12-AS2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated USP12-AS2 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher USP12-AS2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated USP12-AS2 expression acts as an unfavorable survival marker, although some lineages such as PAAD and LUSC show a favorable association.

THCA, PAAD, and LUSC are the cancer types where USP12-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Quartile	All	0.940	0.992	<.001	75	view →
PAAD	OS	Tertile	All	0.660	0.342	<.001	66	view →
LUSC	DFS	Median	II,III,IV	0.790	0.634	<.001	46	view →
MESO	OS	Median	III,IV	0.837	0.253	<.001	42	view →
UVM	DFS	Quartile	All	0.743	0.361	.003	36	view →
STAD	OS	Tertile	IV	0.784	0.110	<.001	32	view →
CHOL	DFS	Median	All	0.710	0.242	.005	30	view →
SKCM	DFS	Quartile	III,IV	0.423	0.165	.002	27	view →
ACC	OS	Quartile	II,III,IV	0.191	0.805	.001	19	view →
UCS	DFS	Quartile	All	0.669	0.170	.001	16	view →
BRCA	OS	Quartile	IV	0.325	0.930	.006	16	view →
TGCT	DFS	Quartile	All	0.958	0.645	.003	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

USP12-AS2–THCA (OS)

Open the THCA breakdown →