USP12-AS2

Across TCGA pan-cancer cohorts, USP12-AS2 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of USP12-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where USP12-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types USP12-AS2 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and KIRC are the cancer types where USP12-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP12-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−1.470	<.001	10	view →
KIRP	All	All	−0.564	<.001	9	view →
KIRC	All	All	−0.415	<.001	5	view →
LIHC	Male	All	+0.623	<.001	3	view →
UCEC	All	All	−0.578	.039	2	view →
HNSC	Male	III,IV	+0.431	.014	2	view →
CHOL	All	II,III,IV	−0.340	.025	2	view →
THCA	All	All	−0.163	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

USP12-AS2–KICH

Open the KICH breakdown →