USP11

Across TCGA cell cohorts, USP11 mutation is significantly associated with the RNA expression of many other genes, with 238 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP11-associated genes across cancer lineages are GPR26, C10orf71, and SLC32A1. Each is linked with USP11 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP11-to-partner and partner-to-USP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR26 grouped by USP11-low versus USP11-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP11→partner) and Y-score (partner→USP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GPR26 →	+0.036	+4.906	<.001	.006	3	1
OESOPHAGUS	C10orf71 →	+0.006	+4.906	<.001	.006	3	1
BLOOD_Leukemia	SLC32A1 →	+1.243	+3.901	<.001	.006	3	1
BLOOD_Leukemia	GML →	+0.060	+4.567	.001	.001	3	1
BLOOD_Leukemia	MMP27 →	+0.015	+4.384	<.001	.006	3	1
BLOOD_Leukemia	AWAT2 →	+0.012	+3.705	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 238 associations by consensus.

GPR26 by USP11 expression — OESOPHAGUS

Explore this box plot interactively →