USH2A

Across TCGA patient cohorts, USH2A RNA expression is significantly associated with the protein abundance of many other proteins, with 13,368 significant associations in total. GBM shows the largest number of these associations.

The most reproducible USH2A-associated proteins across cancer lineages are UPP1, JUNB, and FAM98B. Each is linked with USH2A in more than 4 cancer types. Because this analysis shows association rather than direction, both USH2A-to-partner and partner-to-USH2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USH2A versus UPP1 in GBM, with a Pearson correlation of -0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (USH2A→partner) and Y-score (partner→USH2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UPP1 →	-0.808	-0.269	<.001	<.001	3	5
GBM	JUNB →	-0.400	-0.292	.001	<.001	3	5
GBM	FAM98B →	+0.261	+0.234	<.001	<.001	3	4
HNSC	MAP7D1_S86 →	-1.075	-0.398	<.001	<.001	3	4
HNSC	PLEC_S1888 →	-1.043	-0.341	<.001	<.001	3	4
HNSC	PLEC_S2039 →	-1.043	-0.341	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,368 associations by consensus.

USH2A vs UPP1 — GBM

Explore this scatter interactively →