USH2A

Across TCGA patient cohorts, USH2A mutation is significantly associated with the RNA expression of many other genes, with 11,918 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USH2A-associated genes across cancer lineages are LOXL1, LTBP2, and ADCY4. Each is linked with USH2A in more than 8 cancer types. Because this analysis shows association rather than direction, both USH2A-to-partner and partner-to-USH2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LOXL1 grouped by USH2A-low versus USH2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USH2A→partner) and Y-score (partner→USH2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LOXL1 →	-0.391	-1.447	.001	.001	3	8
LIHC	LTBP2 →	-0.923	-1.918	.001	.005	3	7
STAD	ADCY4 →	-0.380	-2.572	.001	<.001	3	7
STAD	HSPA12B →	-0.477	-1.398	.001	.003	3	7
ESCA	SKA3 →	+0.589	+3.206	.006	.006	3	7
STAD	PODN →	-0.954	-2.231	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,918 associations by consensus.

LOXL1 by USH2A expression — UCEC

Explore this box plot interactively →