USH1C

Across TCGA pan-cancer cohorts, USH1C Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated USH1C data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher USH1C Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated USH1C expression acts as an unfavorable survival marker.

BLCA, LUAD, and LUSC are the cancer types where USH1C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	III,IV	0.136	0.684	<.001	12	view →
LUAD	DFS	Median	IV	0.045	0.717	<.001	12	view →
LUSC	DFS	Median	III,IV	0.079	0.751	.024	7	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SCLC	DFS	Median	II,III,IV	0.219	0.609	.016	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

USH1C–BLCA (OS)

Open the BLCA breakdown →