USH1C

Across TCGA pan-cancer cohorts, USH1C RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of USH1C’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where USH1C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types USH1C is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, KICH, and STAD are the cancer types where USH1C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USH1C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+2.427	<.001	12	view →
KICH	Male	II,III,IV	−4.732	<.001	10	view →
STAD	All	II,III,IV	+2.178	<.001	8	view →
THCA	Male	All	−1.306	<.001	8	view →
CHOL	Female	All	+5.690	<.001	5	view →
LIHC	Male	II,III,IV	+1.563	.004	4	view →
LUAD	All	All	+0.462	.007	4	view →
BLCA	Female	IV	−0.290	<.001	4	view →
READ	All	III,IV	+0.185	.012	2	view →
BRCA	Female	All	−0.170	.021	2	view →
PRAD	All	All	−0.092	.028	2	view →
LUSC	All	All	+0.295	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

USH1C–KIRC

Open the KIRC breakdown →