USH1C

Across TCGA pan-cancer cohorts, USH1C mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated USH1C data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher USH1C mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated USH1C expression acts as an unfavorable survival marker, although some lineages such as PDAC and COAD show a favorable association.

PDAC, COAD, and CCRCC are the cancer types where USH1C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.688	0.384	<.001	116	view →
COAD	DFS	Median	All	1.000	0.920	.014	48	view →
CCRCC	OS	Quartile	II,III,IV	1.000	0.684	.003	44	view →
LUAD	OS	Median	All	0.689	0.207	.009	9	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

USH1C–PDAC (OS)

Open the PDAC breakdown →