USH1C

Across TCGA patient cohorts, USH1C mutation is significantly associated with the RNA expression of many other genes, with 5,860 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USH1C-associated genes across cancer lineages are RANBP1, ITGB1BP1, and DRG1. Each is linked with USH1C in more than 3 cancer types. Because this analysis shows association rather than direction, both USH1C-to-partner and partner-to-USH1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RANBP1 grouped by USH1C-low versus USH1C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USH1C→partner) and Y-score (partner→USH1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RANBP1 →	+0.575	+2.129	<.001	<.001	3	4
UCEC	ITGB1BP1 →	+0.293	+2.332	.001	<.001	3	4
UCEC	DRG1 →	+0.328	+1.604	<.001	<.001	3	4
LUAD	GEMIN2 →	+0.523	+1.895	.001	.004	3	3
LUAD	DSN1 →	+0.487	+1.859	.001	.005	3	3
LUAD	FAM177A1 →	+0.442	+2.168	.008	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,860 associations by consensus.

RANBP1 by USH1C expression — UCEC

Explore this box plot interactively →