USH1C

Across TCGA patient cohorts, USH1C mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USH1C-associated genes across cancer lineages are eEF2, ATM, and Caspase-7-cleavedD198. Each is linked with USH1C in more than 2 cancer types. Because this analysis shows association rather than direction, both USH1C-to-partner and partner-to-USH1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by USH1C-low versus USH1C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USH1C→partner) and Y-score (partner→USH1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.241	+1.064	.028	.048	3	3
UCEC	ATM →	-0.510	-1.999	<.001	.002	3	3
UCEC	Caspase-7-cleavedD198 →	+0.679	+2.019	<.001	.001	3	3
UCEC	A-Raf_pS299 →	-0.102	-1.584	.005	.017	3	2
UCEC	GAPDH →	+0.388	+1.906	.018	.014	3	2
UCEC	INPP4B →	-0.239	-1.584	.015	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

eEF2 by USH1C expression — UCEC

Explore this box plot interactively →