USH1C

Across TCGA cell cohorts, USH1C mutation is significantly associated with the RNA expression of many other genes, with 122 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible USH1C-associated genes across cancer lineages are OR10T2, MMP27, and OR11H6. Each is linked with USH1C in more than 2 cancer types. Because this analysis shows association rather than direction, both USH1C-to-partner and partner-to-USH1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10T2 grouped by USH1C-low versus USH1C-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USH1C→partner) and Y-score (partner→USH1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10T2 →	+0.730	+4.276	<.001	.007	3	3
BLOOD_Leukemia	MMP27 →	+0.019	+4.969	<.001	.003	3	2
BLOOD_Leukemia	OR11H6 →	+0.028	+4.705	<.001	.003	3	2
SKIN	COX4I2 →	+0.060	+2.103	.004	.002	3	2
SKIN	ERC2 →	+0.312	+2.000	<.001	.009	3	2
OESOPHAGUS	TEKT4 →	+0.058	+3.321	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 122 associations by consensus.

OR10T2 by USH1C expression — BLOOD_Leukemia

Explore this box plot interactively →