USE1

Across TCGA patient cohorts, USE1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,071 significant associations in total. GBM shows the largest number of these associations.

The most reproducible USE1-associated genes across cancer lineages are FRMD4B, APAF1, and PPIL4. Each is linked with USE1 in more than 3 cancer types. Because this analysis shows association rather than direction, both USE1-to-partner and partner-to-USE1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USE1 versus FRMD4B in GBM, with a Pearson correlation of -0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USE1→partner) and Y-score (partner→USE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FRMD4B →	-0.638	-0.210	<.001	<.001	3	3
UCEC	APAF1 →	-0.510	-0.537	.001	<.001	3	3
UCEC	PPIL4 →	-0.418	-0.544	.001	<.001	3	3
LUAD	TMTC1 →	-0.770	-0.200	<.001	<.001	3	3
GBM	ANKH →	-0.441	-0.147	<.001	<.001	3	3
GBM	LRRC8C →	-0.348	-0.246	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,071 associations by consensus.

USE1 vs FRMD4B — GBM

Explore this scatter interactively →