USE1

Across TCGA pan-cancer cohorts, USE1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated USE1 data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher USE1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated USE1 expression acts as an unfavorable survival marker, although some lineages such as DLBC and ESCA show a favorable association.

ACC, COAD, and DLBC are the cancer types where USE1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.432	0.835	.002	39	view →
COAD	OS	Tertile	IV	0.315	0.674	.007	38	view →
DLBC	DFS	Tertile	II,III,IV	1.000	0.338	.022	20	view →
STAD	DFS	Median	All	0.560	0.688	.019	20	view →
ESCA	DFS	Tertile	All	1.000	0.492	.012	15	view →
UCEC	OS	Median	All	0.845	0.899	.032	12	view →
KICH	DFS	Tertile	III,IV	0.278	1.000	.033	11	view →
LUAD	DFS	Tertile	II,III,IV	0.419	0.097	.004	10	view →
THYM	OS	Median	All	0.965	0.780	.009	7	view →
KIRP	DFS	Median	All	0.863	0.955	.003	7	view →
LGG	OS	Quartile	All	0.952	0.835	.008	7	view →
SCLC	DFS	Tertile	IV	0.361	0.806	.029	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

USE1–ACC (OS)

Open the ACC breakdown →