USE1

Across TCGA patient cohorts, USE1 mutation is significantly associated with the RNA expression of many other genes, with 857 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USE1-associated genes across cancer lineages are RPS29P9, RNU6-74P, and RPL12P45. Each is linked with USE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both USE1-to-partner and partner-to-USE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS29P9 grouped by USE1-low versus USE1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USE1→partner) and Y-score (partner→USE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPS29P9 →	+0.611	+4.440	<.001	.006	3	3
BLCA	RNU6-74P →	+0.419	+5.106	<.001	.008	3	2
BRCA	RPL12P45 →	+0.095	+5.646	<.001	.004	3	2
UCEC	RNU6-668P →	+0.245	+3.312	<.001	.001	3	2
UCEC	TRAJ27 →	+0.686	+2.282	<.001	.003	3	2
SKCM	ATF4P2 →	+0.042	+4.241	.003	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 857 associations by consensus.

RPS29P9 by USE1 expression — SKCM

Explore this box plot interactively →