USE1

Across TCGA patient cohorts, USE1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USE1-associated genes across cancer lineages are MEK1, eIF4E, and eIF4G. Each is linked with USE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both USE1-to-partner and partner-to-USE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by USE1-low versus USE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USE1→partner) and Y-score (partner→USE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.361	+2.321	.049	.035	3	2
UCEC	eIF4E →	+0.233	+3.169	.027	.019	3	1
UCEC	eIF4G →	+0.317	+2.321	.041	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.221	-2.999	.009	.035	3	1
UCEC	p62 Lck ligand →	+0.566	+3.459	<.001	.005	3	1
UCEC	PCNA →	+0.249	+3.000	.021	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

MEK1 by USE1 expression — UCEC

Explore this box plot interactively →