USB1

Across TCGA patient cohorts, USB1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USB1-associated genes across cancer lineages are JNK_pT183_Y185, MEK1, and MSH6. Each is linked with USB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both USB1-to-partner and partner-to-USB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by USB1-low versus USB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USB1→partner) and Y-score (partner→USB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.202	-3.308	.022	.010	3	1
UCEC	MEK1 →	+0.559	+3.321	.003	.010	3	1
UCEC	MSH6 →	-0.445	-2.990	.010	.036	3	1
UCEC	PREX1 →	-0.313	-3.321	.029	.010	3	1
UCEC	STAT3_pY705 →	-0.468	-2.999	<.001	.035	3	1
UCEC	4E-BP1 →	+0.429	+2.837	.002	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

JNK_pT183_Y185 by USB1 expression — UCEC

Explore this box plot interactively →