USB1

Across TCGA pan-cancer cohorts, USB1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated USB1 data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher USB1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated USB1 expression acts as an unfavorable survival marker, although some lineages such as THYM and SCLC show a favorable association.

MESO, HNSC, and KIRC are the cancer types where USB1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	II,III,IV	0.236	0.529	<.001	120	view →
HNSC	OS	Median	All	0.711	0.792	.001	90	view →
KIRC	DFS	Quartile	All	0.516	0.722	.001	59	view →
BLCA	OS	Tertile	All	0.414	0.797	<.001	54	view →
LIHC	OS	Median	All	0.397	0.632	<.001	51	view →
KIRP	DFS	Tertile	III,IV	0.170	0.855	.017	47	view →
LGG	OS	Median	All	0.748	0.875	<.001	44	view →
SKCM	DFS	Quartile	All	0.652	0.862	.002	24	view →
ACC	OS	Median	IV	0.299	0.741	.002	20	view →
BRCA	OS	Tertile	III,IV	0.842	0.947	.003	16	view →
COAD	DFS	Quartile	All	0.666	0.848	.008	12	view →
LUAD	DFS	Median	All	0.610	0.715	.005	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

USB1–MESO (OS)

Open the MESO breakdown →