USB1

Across TCGA cell cohorts, USB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,570 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible USB1-associated GO terms across cancer lineages are Protein depolymerization, Protein-containing complex disassembly, and Positive regulation of dopamine receptor signaling pathway. Each is linked with USB1 in more than 16 cancer types. Because this analysis shows association rather than direction, both USB1-to-partner and partner-to-USB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein depolymerization grouped by USB1-low versus USB1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USB1→partner) and Y-score (partner→USB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Protein depolymerization →	+0.123	+0.738	.002	.002	3	17
OESOPHAGUS	Protein-containing complex disassembly →	+0.067	+0.816	.002	.005	2	16
BONE	Positive regulation of dopamine receptor signaling pathway →	+0.195	+1.153	<.001	.001	3	14
LUNG_NSCLC_LUSC	Negative regulation of type I interferon production →	+0.118	+0.926	<.001	<.001	3	14
CNS	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.125	+1.078	<.001	<.001	3	13
BONE	Multi-pass transmembrane protein insertion into ER membrane →	+0.130	+1.331	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,570 associations by consensus.

Protein depolymerization by USB1 expression — LUNG_NSCLC_LUSC

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