UROD

Across TCGA patient cohorts, UROD mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UROD-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and EGFR_pY1068. Each is linked with UROD in more than 1 cancer types. Because this analysis shows association rather than direction, both UROD-to-partner and partner-to-UROD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by UROD-low versus UROD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UROD→partner) and Y-score (partner→UROD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.699	+2.189	.008	.034	3	2
UCEC	14-3-3_beta →	-0.118	-1.986	.009	.032	3	1
UCEC	EGFR_pY1068 →	-0.336	-3.169	.002	.018	3	1
UCEC	A-Raf_pS299 →	-0.188	-2.999	<.001	.035	3	1
UCEC	FoxM1 →	+0.267	+2.000	.022	.032	3	1
UCEC	HSP70 →	-0.357	-2.700	.048	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Caspase-7-cleavedD198 by UROD expression — UCEC

Explore this box plot interactively →