UROD

Across TCGA pan-cancer cohorts, UROD RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of UROD’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where UROD RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UROD is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KIRC, KICH, and LIHC are the cancer types where UROD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UROD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	+0.728	<.001	12	view →
KICH	Female	II,III,IV	−1.162	<.001	8	view →
LIHC	Male	All	+0.614	<.001	8	view →
HNSC	Female	All	+0.465	.016	6	view →
BRCA	Female	II,III,IV	−0.390	<.001	6	view →
THCA	All	IV	−0.547	.001	4	view →
CHOL	Female	All	+0.996	<.001	2	view →
UCEC	All	All	−0.416	.017	2	view →
ESCA	All	All	+0.394	.006	2	view →
COAD	Female	All	+0.340	.026	2	view →
PRAD	All	All	−0.310	<.001	2	view →
BLCA	All	IV	−0.474	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

UROD–KIRC

Open the KIRC breakdown →