UQCRH

Across TCGA pan-cancer cohorts, UQCRH mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated UQCRH data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UQCRH mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated UQCRH expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

HNSC, GBM, and CCRCC are the cancer types where UQCRH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.710	0.895	.012	10	view →
GBM	OS	Tertile	All	0.917	0.764	.035	2	view →
CCRCC	DFS	Median	III,IV	1.000	0.451	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

UQCRH–HNSC (DFS)

Open the HNSC breakdown →