UQCRFS1

Across TCGA patient cohorts, UQCRFS1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UQCRFS1-associated genes across cancer lineages are INPP4B, MSH2, and TFRC. Each is linked with UQCRFS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UQCRFS1-to-partner and partner-to-UQCRFS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by UQCRFS1-low versus UQCRFS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UQCRFS1→partner) and Y-score (partner→UQCRFS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.369	-2.986	.048	.037	3	1
UCEC	MSH2 →	-0.316	-3.000	.017	.037	3	1
UCEC	TFRC →	+0.740	+3.000	.015	.037	3	1
UCEC	4E-BP1_pS65 →	-0.329	-2.986	.003	.037	2	1
UCEC	4E-BP1_pT37_T46 →	-0.433	-3.000	.046	.037	2	1
UCEC	Myosin-IIa_pS1943 →	+0.270	+3.013	.023	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

INPP4B by UQCRFS1 expression — UCEC

Explore this box plot interactively →