UQCRFS1

Across TCGA pan-cancer cohorts, UQCRFS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of UQCRFS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where UQCRFS1 RNA is repressed in tumor relative to normal tissue. In most cancer types UQCRFS1 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where UQCRFS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UQCRFS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.296	<.001	11	view →
COAD	All	IV	−0.979	<.001	11	view →
KIRP	Male	III,IV	−0.846	<.001	9	view →
THCA	Male	III,IV	−0.727	<.001	9	view →
LIHC	Female	All	+0.735	<.001	7	view →
HNSC	All	All	−0.305	.001	7	view →
LUSC	All	II,III,IV	+0.892	<.001	6	view →
CHOL	Female	All	+0.849	.005	4	view →
READ	All	All	−0.723	.003	2	view →
BLCA	All	IV	−0.298	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

UQCRFS1–KIRC

Open the KIRC breakdown →