UQCRC1

Across TCGA patient cohorts, UQCRC1 mutation is significantly associated with the RNA expression of many other genes, with 338 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UQCRC1-associated genes across cancer lineages are OFD1P11Y, RNU6-1216P, and RNU6-391P. Each is linked with UQCRC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UQCRC1-to-partner and partner-to-UQCRC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OFD1P11Y grouped by UQCRC1-low versus UQCRC1-high in THCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UQCRC1→partner) and Y-score (partner→UQCRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	OFD1P11Y →	+0.019	+7.962	<.001	.007	3	2
SKCM	RNU6-1216P →	+0.463	+3.533	<.001	.007	3	2
UCEC	RNU6-391P →	+0.162	+2.912	.003	.009	3	2
THCA	SNORD115-3 →	+0.364	+7.962	<.001	.007	3	1
SKCM	RPL7L1P13 →	+0.059	+3.766	<.001	.005	3	1
SKCM	RNU6-1234P →	+0.405	+3.817	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 338 associations by consensus.

OFD1P11Y by UQCRC1 expression — THCA

Explore this box plot interactively →