UQCRB

Across TCGA pan-cancer cohorts, UQCRB mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated UQCRB data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher UQCRB mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated UQCRB expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

COAD, LSCC, and OV are the cancer types where UQCRB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.912	.013	36	view →
LSCC	DFS	Tertile	II,III,IV	0.965	0.691	.004	29	view →
OV	DFS	Median	All	1.000	0.850	.026	12	view →
LUAD	OS	Quartile	All	0.613	0.931	.018	7	view →
CCRCC	OS	Tertile	All	1.000	0.600	.022	7	view →
PDAC	OS	Quartile	All	0.701	0.392	.003	6	view →
HNSC	DFS	Median	II,III,IV	0.904	0.984	.028	5	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

UQCRB–COAD (DFS)

Open the COAD breakdown →