UQCRB

Across TCGA pan-cancer cohorts, UQCRB RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of UQCRB’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where UQCRB RNA is repressed in tumor relative to normal tissue. In most cancer types UQCRB is over-expressed in tumor, although a few such as BLCA and KIRC show the opposite, repressed pattern.

BLCA, LIHC, and CHOL are the cancer types where UQCRB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UQCRB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−0.784	<.001	10	view →
LIHC	Male	II,III,IV	+1.234	<.001	9	view →
CHOL	All	All	+1.381	<.001	5	view →
KIRC	Male	All	−0.239	.004	3	view →
KICH	All	IV	+0.762	.026	1	view →
READ	Female	All	−0.666	.016	1	view →
THCA	Male	II,III,IV	−0.349	.023	1	view →
COAD	All	All	−0.247	.037	1	view →
KIRP	All	All	−0.230	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

UQCRB–BLCA

Open the BLCA breakdown →