UQCRB

Across TCGA patient cohorts, UQCRB mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UQCRB-associated genes across cancer lineages are p27, Rab25, and Tuberin. Each is linked with UQCRB in more than 1 cancer types. Because this analysis shows association rather than direction, both UQCRB-to-partner and partner-to-UQCRB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27 grouped by UQCRB-low versus UQCRB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UQCRB→partner) and Y-score (partner→UQCRB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27 →	-0.321	-3.000	.011	.037	3	1
UCEC	Rab25 →	-0.387	-3.000	.043	.037	2	1
UCEC	Tuberin →	+0.503	+2.817	.001	.036	2	1
UCEC	Bax →	+0.289	+2.817	.037	.036	2	1
UCEC	Caveolin-1 →	-0.946	-3.000	.024	.037	2	1
UCEC	eIF4E →	+0.256	+3.000	.035	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

p27 by UQCRB expression — UCEC

Explore this box plot interactively →