UPP2-IT1

Across TCGA pan-cancer cohorts, UPP2-IT1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated UPP2-IT1 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher UPP2-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated UPP2-IT1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and OV show a favorable association.

MESO, UCEC, and OV are the cancer types where UPP2-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	IV	0.077	0.638	<.001	90	view →
UCEC	OS	Tertile	II,III,IV	0.893	0.707	.001	62	view →
OV	OS	Median	III,IV	0.864	0.818	.021	46	view →
CHOL	OS	Quartile	II,III,IV	0.060	0.772	<.001	34	view →
LUAD	OS	Tertile	All	0.861	0.795	.023	27	view →
BLCA	OS	Tertile	IV	0.185	0.599	.012	24	view →
KIRP	DFS	Quartile	All	1.000	0.570	.008	22	view →
ACC	DFS	Tertile	III,IV	0.046	0.670	.001	18	view →
KIRC	DFS	Tertile	All	0.919	0.804	.025	14	view →
PAAD	DFS	Tertile	All	0.426	0.170	.010	13	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →
PCPG	DFS	Median	All	0.977	0.819	.011	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

UPP2-IT1–MESO (OS)

Open the MESO breakdown →