UPP2-IT1

Across TCGA pan-cancer cohorts, UPP2-IT1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of UPP2-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where UPP2-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types UPP2-IT1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, THCA, and KIRC are the cancer types where UPP2-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UPP2-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.448	<.001	6	view →
THCA	All	All	+0.240	<.001	5	view →
KIRC	Male	All	−0.277	<.001	2	view →
KIRP	All	All	−0.276	.037	2	view →
LUSC	Male	All	−0.045	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

UPP2-IT1–KICH

Open the KICH breakdown →