UPK3A

Across TCGA pan-cancer cohorts, UPK3A Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated UPK3A data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher UPK3A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated UPK3A expression acts as an unfavorable survival marker.

CESC, BLCA, and ACC are the cancer types where UPK3A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	II,III,IV	0.068	0.830	<.001	24	view →
BLCA	OS	Median	III,IV	0.089	0.684	<.001	24	view →
ACC	OS	Median	All	0.216	0.627	.029	4	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

UPK3A–CESC (OS)

Open the CESC breakdown →