UPK3A

Across TCGA pan-cancer cohorts, UPK3A RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of UPK3A’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where UPK3A RNA is repressed in tumor relative to normal tissue. In most cancer types UPK3A is over-expressed in tumor, although a few such as THCA and HNSC show the opposite, repressed pattern.

THCA, LUAD, and LIHC are the cancer types where UPK3A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UPK3A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−3.585	<.001	11	view →
LUAD	Female	All	+1.269	<.001	7	view →
LIHC	All	All	+1.378	<.001	6	view →
HNSC	Male	All	−0.781	<.001	6	view →
KIRC	Male	All	+0.310	<.001	6	view →
STAD	All	All	+1.610	.002	5	view →
CHOL	All	All	+1.989	.004	4	view →
COAD	All	All	+0.854	.004	4	view →
LUSC	Male	III,IV	−0.507	.002	4	view →
BRCA	Female	All	−0.306	.043	2	view →
KICH	All	III,IV	−0.304	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

UPK3A–THCA

Open the THCA breakdown →