UPK3A

Across TCGA pan-cancer cohorts, UPK3A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UPK3A data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher UPK3A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated UPK3A expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, PDAC, and LSCC are the cancer types where UPK3A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	1.000	0.622	.012	34	view →
PDAC	OS	Quartile	All	1.000	0.661	.003	23	view →
LSCC	DFS	Quartile	All	0.215	0.790	.038	3	view →
CCRCC	DFS	Median	All	0.935	0.624	.033	2	view →
GBM	DFS	Quartile	All	0.853	0.578	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UPK3A–UCEC (OS)

Open the UCEC breakdown →