UPK3A

Across TCGA patient cohorts, UPK3A protein abundance is significantly associated with the RNA expression of many other genes, with 5,361 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible UPK3A-associated genes across cancer lineages are REPS2, BBOF1, and TMEM125. Each is linked with UPK3A in more than 6 cancer types. Because this analysis shows association rather than direction, both UPK3A-to-partner and partner-to-UPK3A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, UPK3A versus REPS2 in BRCA, with a Pearson correlation of 0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPK3A→partner) and Y-score (partner→UPK3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	REPS2 →	+1.752	+1.196	<.001	<.001	3	7
BRCA	BBOF1 →	+0.865	+1.004	.001	<.001	3	3
GBM	TMEM125 →	+1.777	+0.746	<.001	<.001	3	3
LSCC	ZMYND10 →	+1.145	+0.671	.004	.001	3	3
UCEC	ALDH6A1 →	+0.905	+0.481	.002	<.001	3	3
BRCA	MCCC2 →	+1.084	+1.051	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,361 associations by consensus.

UPK3A vs REPS2 — BRCA

Explore this scatter interactively →