UPK3A

Across TCGA cell cohorts, UPK3A RNA expression is significantly associated with the go_rna of many other GO terms, with 1,005 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UPK3A-associated GO terms across cancer lineages are Lateral line system development, Dicarboxylic acid biosynthetic process, and Positive regulation of blood-brain barrier permeability. Each is linked with UPK3A in more than 5 cancer types. Because this analysis shows association rather than direction, both UPK3A-to-partner and partner-to-UPK3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lateral line system development grouped by UPK3A-low versus UPK3A-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UPK3A→partner) and Y-score (partner→UPK3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Lateral line system development →	+1.597	+0.838	<.001	.007	3	6
OVARY	Dicarboxylic acid biosynthetic process →	-0.259	-0.363	<.001	.001	3	6
PANCREAS	Positive regulation of blood-brain barrier permeability →	+0.252	+0.603	.005	.004	3	5
LUNG_SCLC	Membrane bending →	+0.091	+0.208	.002	.002	2	6
STOMACH	Response to Gram-positive bacterium →	+0.149	+0.327	.005	.003	3	5
OVARY	Cell-cell adhesion mediated by cadherin →	+0.179	+0.267	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,005 associations by consensus.

Lateral line system development by UPK3A expression — PANCREAS

Explore this box plot interactively →