UPK2

Across TCGA patient cohorts, UPK2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UPK2-associated genes across cancer lineages are INPP4B, Smad3, and STAT3_pY705. Each is linked with UPK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UPK2-to-partner and partner-to-UPK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by UPK2-low versus UPK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPK2→partner) and Y-score (partner→UPK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.382	-3.000	.024	.036	3	1
UCEC	Smad3 →	+0.182	+3.169	.021	.019	3	1
UCEC	STAT3_pY705 →	-0.489	-3.321	<.001	.010	3	1
UCEC	AR →	-0.510	-3.321	.009	.010	3	1
UCEC	Bak →	+0.272	+3.000	.038	.036	3	1
UCEC	EGFR_pY1068 →	-0.348	-3.321	.008	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

INPP4B by UPK2 expression — UCEC

Explore this box plot interactively →