UPK2

Across TCGA pan-cancer cohorts, UPK2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated UPK2 data layer compared with 3 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher UPK2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated UPK2 expression acts as an unfavorable survival marker, although some lineages such as UVM and LGG show a favorable association.

UVM, BRCA, and ACC are the cancer types where UPK2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.772	0.327	<.001	106	view →
BRCA	OS	Median	II,III,IV	0.885	0.941	<.001	98	view →
ACC	DFS	Median	All	0.218	0.684	<.001	92	view →
SCLC	OS	Tertile	III,IV	0.340	0.730	<.001	88	view →
HNSC	OS	Tertile	All	0.254	0.454	<.001	80	view →
PAAD	DFS	Median	All	0.391	0.576	<.001	63	view →
LGG	DFS	Median	All	0.834	0.634	<.001	54	view →
KIRC	DFS	Tertile	II,III,IV	0.303	0.653	.002	43	view →
KIRP	DFS	Tertile	All	0.819	0.963	<.001	40	view →
COAD	DFS	Quartile	All	0.732	0.869	<.001	39	view →
UCS	DFS	Tertile	II,III,IV	0.650	0.148	<.001	38	view →
SKCM	OS	Median	II,III,IV	0.631	0.811	.004	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

UPK2–UVM (DFS)

Open the UVM breakdown →