UPK2

Across TCGA cell cohorts, UPK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,391 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UPK2-associated GO terms across cancer lineages are Regulation of ruffle assembly, Mammary gland morphogenesis, and Response to indole-3-methanol. Each is linked with UPK2 in more than 10 cancer types. Because this analysis shows association rather than direction, both UPK2-to-partner and partner-to-UPK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of ruffle assembly grouped by UPK2-low versus UPK2-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UPK2→partner) and Y-score (partner→UPK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Regulation of ruffle assembly →	+0.173	+2.170	<.001	<.001	3	11
STOMACH	Mammary gland morphogenesis →	+0.187	+3.198	.002	<.001	3	9
URINARY_TRACT	Response to indole-3-methanol →	+0.242	+3.644	<.001	<.001	3	9
LUNG_NSCLC_LUAD	Cellular response to indole-3-methanol →	+0.213	+2.123	<.001	<.001	3	9
URINARY_TRACT	Small GTPase-mediated signal transduction →	+0.049	+3.050	<.001	<.001	3	9
OESOPHAGUS	Antimicrobial peptide production →	+1.417	+2.727	.003	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,391 associations by consensus.

Regulation of ruffle assembly by UPK2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →