UPK2

Across TCGA cell cohorts, UPK2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UPK2-associated genes across cancer lineages are LGI1, PRKAG3, and MMP20. Each is linked with UPK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UPK2-to-partner and partner-to-UPK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LGI1 grouped by UPK2-low versus UPK2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPK2→partner) and Y-score (partner→UPK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LGI1 →	+0.096	+4.539	<.001	.007	3	1
BLOOD_Leukemia	PRKAG3 →	+0.045	+4.551	<.001	.004	3	1
BLOOD_Leukemia	MMP20 →	+0.061	+4.705	<.001	.003	3	1
BLOOD_Leukemia	ZIC3 →	+0.019	+5.060	<.001	.001	3	1
BLOOD_Leukemia	DEFB4A →	+0.159	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	TRIM49B →	+0.135	+4.874	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

LGI1 by UPK2 expression — BLOOD_Leukemia

Explore this box plot interactively →