UPK1B

Across TCGA pan-cancer cohorts, UPK1B mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated UPK1B data layer compared with 26 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UPK1B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated UPK1B expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where UPK1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.796	0.489	.005	12	view →
PDAC	DFS	Median	II,III,IV	0.913	0.713	.030	3	view →
LSCC	DFS	Median	All	0.816	0.601	.014	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

UPK1B–HNSC (DFS)

Open the HNSC breakdown →