UPF3A

Across TCGA patient cohorts, UPF3A mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UPF3A-associated genes across cancer lineages are MSH2, ASNS, and 14-3-3_beta. Each is linked with UPF3A in more than 1 cancer types. Because this analysis shows association rather than direction, both UPF3A-to-partner and partner-to-UPF3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by UPF3A-low versus UPF3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPF3A→partner) and Y-score (partner→UPF3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.230	-2.973	.018	.035	3	2
UCEC	ASNS →	+0.465	+1.700	.002	.044	3	2
UCEC	14-3-3_beta →	-0.103	-3.295	.015	.009	3	1
UCEC	JNK2 →	+0.267	+3.594	.001	.001	3	1
UCEC	mTOR_pS2448 →	-0.146	-2.439	.020	.019	3	1
UCEC	p62 Lck ligand →	+0.386	+3.321	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

MSH2 by UPF3A expression — UCEC

Explore this box plot interactively →