UPF3A

Across TCGA pan-cancer cohorts, UPF3A RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated UPF3A data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher UPF3A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated UPF3A expression acts as an unfavorable survival marker, although some lineages such as PAAD and STAD show a favorable association.

ACC, PAAD, and CESC are the cancer types where UPF3A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Quartile	II,III,IV	0.094	0.833	.001	68	view →
PAAD	OS	Quartile	II,III,IV	0.692	0.291	.003	45	view →
CESC	DFS	Median	All	0.767	0.875	.001	38	view →
LIHC	OS	Quartile	II,III,IV	0.489	0.792	.004	28	view →
STAD	OS	Quartile	II,III,IV	0.892	0.473	.006	26	view →
UVM	OS	Median	III,IV	0.296	1.000	.005	25	view →
KIRP	DFS	Tertile	All	0.879	0.580	.013	25	view →
GBM	DFS	Tertile	All	0.429	0.187	.003	24	view →
KICH	DFS	Tertile	III,IV	0.467	1.000	.006	22	view →
UCS	DFS	Tertile	IV	0.874	0.296	.024	20	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	20	view →
BLCA	OS	Median	II,III,IV	0.778	0.656	.008	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

UPF3A–ACC (DFS)

Open the ACC breakdown →