UPF3A

Across TCGA cell cohorts, UPF3A mutation is significantly associated with the RNA expression of many other genes, with 267 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UPF3A-associated genes across cancer lineages are TFDP3, LCE2A, and OR2J1. Each is linked with UPF3A in more than 1 cancer types. Because this analysis shows association rather than direction, both UPF3A-to-partner and partner-to-UPF3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFDP3 grouped by UPF3A-low versus UPF3A-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPF3A→partner) and Y-score (partner→UPF3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TFDP3 →	+0.013	+5.000	<.001	.006	3	1
PANCREAS	LCE2A →	+0.033	+5.614	<.001	.002	3	1
PANCREAS	OR2J1 →	+0.006	+5.614	<.001	.002	3	1
PANCREAS	XKR4 →	+0.059	+5.000	<.001	.006	3	1
LUNG_NSCLC_LUAD	PLA2G2E →	+0.070	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR8B4 →	+0.034	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 267 associations by consensus.

TFDP3 by UPF3A expression — PANCREAS

Explore this box plot interactively →