UPF2

Across TCGA pan-cancer cohorts, UPF2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UPF2 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher UPF2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UPF2 expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

PDAC, GBM, and CCRCC are the cancer types where UPF2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	IV	0.381	0.951	.006	14	view →
GBM	DFS	Tertile	All	0.387	0.197	.004	12	view →
CCRCC	DFS	Tertile	III,IV	0.887	0.198	.024	5	view →
UCEC	OS	Quartile	All	0.904	1.000	.044	2	view →
LUAD	DFS	Median	All	0.966	0.831	.008	1	view →
HNSC	OS	Quartile	IV	0.950	0.634	.020	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

UPF2–PDAC (OS)

Open the PDAC breakdown →