UPF2

Across TCGA cell cohorts, UPF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,025 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible UPF2-associated GO terms across cancer lineages are Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, and Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Each is linked with UPF2 in more than 19 cancer types. Because this analysis shows association rather than direction, both UPF2-to-partner and partner-to-UPF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay grouped by UPF2-low versus UPF2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UPF2→partner) and Y-score (partner→UPF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.141	+0.924	<.001	<.001	3	20
KIDNEY	Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.081	+0.515	<.001	.002	3	14
BONE	Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.101	+0.794	<.001	<.001	3	14
SOFT_TISSUE	Subtelomeric heterochromatin formation →	+0.096	+0.746	<.001	<.001	3	13
BONE	Double-strand break repair via nonhomologous end joining →	+0.045	+0.439	.005	.007	2	13
BONE	Protein localization to chromosome →	+0.104	+0.654	.008	.005	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,025 associations by consensus.

Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay by UPF2 expression — UPPER_AERODIGESTIVE_TRACT

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